DYDROGESTERONE 10 MG TABLET

DISCRIPTION

Dyorone Tablet is a combination of (Dydrogesterone 10 mg) are synthetic progestogens used to address various female reproductive health concerns. They function similarly to the natural hormone progesterone, aiding in regulating menstrual cycles and supporting pregnancy.Commonly prescribed for conditions like irregular periods, painful menstruation, and endometriosis, Dyorone Tablet (Dydrogesterone 10 mg) helps alleviate symptoms associated with hormonal imbalances. Additionally, it is utilized to prevent recurrent miscarriages by supporting the uterine lining during early pregnancy.In hormone replacement therapy, Dyorone Tablet (Dydrogesterone 10 mg) protects the uterine lining in postmenopausal women receiving estrogen therapy. The typical dosage involves taking 10 mg tablets, with frequency and duration determined by the specific condition being treated. While generally well-tolerated, some individuals may experience side effects such as nausea, headache, breast tenderness, and mood changes.It's essential to use Dyorone Tablet (Dydrogesterone 10 mg) under medical supervision, especially for individuals with certain health conditions. Always consult a healthcare professional before initiating treatment with this medication.

INDICATION

1. Menstrual Disorders : Dyorone Tablet (Dydrogesterone 10 mg) is effective in managing various menstrual irregularities. It helps regulate cycles by supporting the normal growth and shedding of the uterine lining. Conditions such as absent or irregular menstruation, painful menstruation (dysmenorrhea), and premenstrual syndrome (PMS) can be alleviated with its use. By mimicking natural progesterone, it restores hormonal balance, leading to more regular and less painful menstrual cycles.

2. Dysmenorrhea (Painful Menstruation) : Dysmenorrhea, characterized by severe menstrual cramps, affects a significant number of women. Dyorone Tablet (Dydrogesterone 10 mg) has been shown to reduce the severity of menstruation-related lower abdominal pain, low back pain, headache, and nausea/vomiting. In a clinical study, the total dysmenorrhea score decreased significantly after treatment with Dyorone Tablet (Dydrogesterone 10 mg), indicating its efficacy in pain management.

3. Secondary Amenorrhea : Secondary amenorrhea refers to the absence of menstruation in women who previously had regular cycles. Dyorone Tablet (Dydrogesterone 10 mg) induces regular withdrawal bleeding in such cases, effectively restoring menstrual cycles. A randomized controlled study demonstrated that cyclical administration of Dyorone Tablet (Dydrogesterone 10 mg) led to a higher incidence of withdrawal bleeding compared to placebo, highlighting its role in managing secondary amenorrhea.

4. Dysfunctional Uterine Bleeding : Dyorone Tablet (Dydrogesterone 10 mg) is utilized to control abnormal uterine bleeding, a condition where the menstrual flow is irregular or excessively heavy. It helps normalize the endometrial lining, thereby regulating bleeding patterns. In cases of unexpected bleeding, Dyorone Tablet (Dydrogesterone 10 mg) can be administered to stop the bleeding, and for ongoing prevention, it can be taken cyclically to maintain regular menstrual cycles.

5. Endometriosis : Endometriosis involves the growth of endometrial tissue outside the uterus, leading to pain and potential fertility issues. Dyorone Tablet (Dydrogesterone 10 mg) alleviates pain associated with endometriosis by counteracting the effects of estrogen, which is responsible for the growth and inflammation of endometrial tissues outside the uterus. Unlike some treatments, Dyorone Tablet (Dydrogesterone 10 mg) does not inhibit ovulation, making it a suitable option for women seeking to maintain fertility.

6. Infertility Due to Luteal Phase Insufficiency : Luteal phase insufficiency occurs when the body does not produce enough progesterone after ovulation, leading to difficulties in maintaining pregnancy. Dyorone Tablet (Dydrogesterone 10 mg) supports the luteal phase by supplementing progesterone levels, thereby enhancing the chances of successful embryo implantation and early pregnancy maintenance. Its oral administration offers convenience and improved patient compliance compared to other forms of progesterone supplementation.

7. Threatened or Habitual Miscarriage : In cases of threatened miscarriage, characterized by bleeding during early pregnancy with a closed cervix, Dyorone Tablet (Dydrogesterone 10 mg) helps maintain the uterine lining and supports pregnancy. For women with a history of recurrent miscarriages, Dyorone Tablet (Dydrogesterone 10 mg) has been associated with a significant reduction in miscarriage rates, making it a valuable option for preventing pregnancy loss.

8. Hormone Replacement Therapy (HRT) : In postmenopausal women with an intact uterus, estrogen therapy can increase the risk of endometrial hyperplasia and cancer. Dyorone Tablet (Dydrogesterone 10 mg) is used in combination with estrogen to protect the endometrial lining. It helps reduce the risk of endometrial hyperplasia and cancer that can result from unopposed estrogen therapy.

MECHANISM OF ACTION

Dydrogesterone 10 mg is a synthetic progestogen that mimics the actions of natural progesterone in the body. Its mechanism of action involves binding to progesterone receptors (PR-A and PR-B) in target tissues, such as the endometrium, to initiate gene transcription that supports the luteal phase of the menstrual cycle and early pregnancy. Unlike some other progestins, dydrogesterone exhibits high selectivity for progesterone receptors, minimizing interactions with androgenic, estrogenic, or glucocorticoid receptors, which reduces the risk of side effects. Upon oral administration, dydrogesterone is metabolized to its active metabolite, 20α-dihydrodydrogesterone (DHD), which further contributes to its progestogenic effects. This selective binding and metabolic profile enhance its efficacy and safety profile compared to other progestogens.

SIDE EFFECT OF DYORONE TAB
Major & Minor side effects for Dyorone Tab

• Abdominal pain
• Bloating
• Headache
• Dizziness
• Depression
• Breast tenderness
• Hot flushes
• Vaginal discharge

DRUG INDICATION

Drug-Drug Interactions: This medicine may interact with medications, including anticonvulsants (e.g. acetazolamide, carbamazepine), anti-infectives (e.g. metronidazole, clindamycin), and certain herbal preparations (e.g. Ginkgo Biloba).

Drug-Food Interactions: Dyorone Tablet (Dydrogesterone 10 mg) may interact with grapefruit or grapefruit juice and St. John’s wort plant (used for anti-depression). 

Drug-Disease Interactions: Dyorone Tablet (Dydrogesterone 10 mg) may interact with disease conditions, including breast cancer, liver disease, thromboembolism, depression, fluid retention (oedema), glucose intolerance, retinal thrombosis (blocked vein of the retina of the eye), thyroid disease, high cholesterol (hyperlipidemia), uterine bleeding, ovarian cyst, and weight gain (obesity).

PRECAUTION

Before using Dyorone Tablet (Dydrogesterone 10 mg), inform your healthcare provider if you have a history of liver disease, kidney impairment, blood clotting disorders, or depression. The medication may cause dizziness; avoid driving or operating heavy machinery if affected. Regular monitoring of liver function and awareness of potential side effects is recommended during treatment.

DISCLAIMER
 

The information on this website is provided for general informational purposes only and is not medical advice. It is not a substitute for professional medical advice, diagnosis, or treatment. Consult a qualified healthcare provider for personalized advice. We do not endorse any specific products, treatments, or services mentioned.